Symposium — Sunday, April 23, 2017 — 10:30 AM - 12:30 PM — , Room W193
Muscle Biology Group — Chair: John J. McCarthy — Co-Chair:
A principal determinant of skeletal muscle mass is the relationship between protein synthesis and protein degradation; a sustained, net increase in the rate of protein synthesis leads to the accumulation of cellular protein resulting in muscle fiber hypertrophy. The rate of protein synthesis is primarily determined by two factors, translational efficiency and translational capacity. Although there exists a large body of work describing the importance of translational efficiency in skeletal muscle hypertrophy, far less attention has been given to the role of translational capacity in promoting hypertrophic growth. Given that ribosome biogenesis is directly responsible for determining the translational capacity of the cell, the symposium will focus on the regulation of ribosome biogenesis during skeletal muscle hypertrophy. Experts in the field will discuss what is currently known about the regulation of ribosome biogenesis, 1) at the level of ribosomal DNA transcription, 2) by mTORC1 signaling, 3) the impact of exercise mode and diet and 4) in response to resistance exercise in humans. The goal of the symposium is to provide attendees with the latest findings on the role of ribosome biogenesis in skeletal muscle hypertrophy and discuss the future direction of the field.