Symposium — Tuesday, April 25, 2017 — 8:00 AM - 10:00 AM — , Room W190A
American Society for Human Genetics (ASHG) — Chair: Erica Davis — Co-Chair: Bina Joe
This special Symposium is a collaboration between the American Society of Human Genetics (ASHG) and the American Physiological Society (APS). Since the turn of this century, we have made great strides in our ability to delineate and compare the primary sequences of our genomes and amassed a wealth of information on genetic variation implicated in a variety of complex traits relevant to human health. However, knowledge of the existence of genomic variations per se is insufficient to translate genetic/genomic discoveries into application for precision medicine. Critical gaps remain in our understanding of how genomic variations mechanistically impact our physiology and pathophysiology. Driven by this unmet need, this session will bring together speakers from both societies to discuss the intersection between, and the interdependence of, genetics and physiology. Using cardiovascular diseases as examples, a panel of distinguished speakers will discuss existing strategies to characterize how genetic variation influences cardiovascular physiology. Given the diversity of the expertise drawn from both the Societies, the content of the session will range from clinical data and human studies to choices of pre-clinical animal and cellular models, highlighting cutting-edge approaches in genetics and physiology through the description of new, exciting results. Besides emphasizing recent progress, another goal of this session is to describe current limitations through discussions and debates, which may spark ideas of collaborations between members of our two societies in order to develop a genetically-informed cardiovascular physiology in health and diseases.