Satellite Cells: External and systemic influences

Featured Topic — Wednesday, April 26, 2024 — 8:00 AM - 10:00 AM — , Room W196A
Muscle Biology Group — Chair: Naomi Brooks — Co-Chair: Esther Dupont-Versteegden

The main roles of satellite cells in the adult are repair of damaged tissue, maintenance of the satellite cell pool and participation in skeletal muscle adaptation. Although pools of adult progenitor cells are influenced mainly by the micro-environments in their confined niches, it is becoming increasingly apparent that a variety of external factors influence skeletal muscle satellite cells. Within the context of skeletal muscle, the main environmental factor influencing satellite cells is mechanical loading/ unloading.  Understanding the adaptation of satellite cells to stressors such as increased load, running and hypoxia will provide insight into the response of skeletal muscle.  Further, the molecular and cellular responses of satellite cells to stress and aging and the impact that these have on muscle regeneration are important to our understanding of satellite cells. This featured topic will discuss recent advances in our understanding of satellite cell responses to growth and adaptation in adult and aging skeletal muscle.

Speakers

• Introduction
  Esther Dupont-Versteegden — Coll of Hlth Sci, Univ. of Kentucky


• The regulation of muscle satellite cells during stress and aging
  Andrew Brack — Department of Orthopaedic Surgery, University of California, San Francisco