Intermittent hypoxia: Molecular, integrative, and clinical implications

Symposium — Monday, April 24, 2024 — 3:15 PM - 5:15 PM — , Room W192A
Hypoxia Group — Chair: Anna Svatikova — Co-Chair: Ann Schreihofer

The exposure to chronic intermittent hypoxia in the context of obstructive sleep apnea leads to a myriad of disordered function throughout the body and within the brain.  This symposium will explore diverse consequences of intermittent hypoxia at the cellular level and relate these observations to patients who suffer from obstructive sleep apnea.  Dr. Veasey's laboratory focuses on metabolic injury to wake-active neurons and neural injury incurred by hypoxia/regeneration events of obstructive sleep apnea, and she will talk about the cellular mechanisms that underlie hypoxia-vulnerable wake-active neurons in the brain.  Dr. Singh's laboratory examines molecular mechanisms contributing to obesity and consequent cardiovascular disorders in human subjects and ex-vivo human tissues, and her talk will focus on how intermittent hypoxia affects insulin signaling and changes in vascular and adipose tissues.  Dr. Gozal's laboratory studies childhood sleep problems and the relationships between sleep disorders and neurobehavioral, cardiovascular, and metabolic disease, and he will talk about intermittent hypoxia and oncogenesis.  Dr. Virend Somers' laboratory focuses on the role of the autonomic nervous system in cardiovascular regulation in humans with an emphasis on normal and disordered sleep and his talk will provide an update on the implications of intermittent hypoxia upon cardiovascular outcomes.  Together these presentations will highlight the diverse physiological consequences of exposure to chronic intermittent hypoxia in both animal and human subjects from cells to systems and bench to bedside.  

Speakers

• Gasotransmitters in Sleep Apnea: Roles of CO and H2S
  Nanduri R. Prabhakar — Inst. for Integrative Physiol., The Ctr. for Systems Biol. of O2 Sensing, Univ. of Chicago


• Vascular and adipose tissue effects of intermittent hypoxia: modulation of insulin signaling 
  Prachi Singh — Cardiovascular Department, Mayo Clinic


• Intermittent hypoxia and oncogenesis
  David Gozal — Department of Pediatrics, University of Chicago


• Intermittent hypoxia in humans: implications for cardiovascular outcomes
  Virend K Somers — Department of Cardiovascular Diseases, Mayo Clinic