Multi-omics to Study the Cellular Pathophysiology of Neurodegenerative Diseases

Symposium — Tuesday, April 25, 2024 — 3:15 PM - 5:15 PM — , Room W194B
Cell and Molecular Physiology Section — Chair: Sanjay Pimplikar — Co-Chair: Li-Huei Tsai

There is a growing appreciation that disorders of the nervous system such as Autism spectrum disorder (ASD), Alzheimers disease (AD), Parkinsons disease (PD) have a complex etiology as well as a highly diverse rate of disease progression. Recent studies show that dynamic interactions between scores of genes, signaling pathways and metabolic networks modulate pathogenesis of these complex disorders. Yet, conventional cellular and molecular tools of investigations reveal only a sliver of the disease mechanisms. New approaches of Omics, systems biology, large-data, computational and statistical analyses are needed to gain a better understanding. This symposium will present studies based on  cutting-edge Multi-omics approaches that encompass epigenomics (Dr. Tsai), genomics (Prof. Goate), transcriptomics (Dr. Zhang), proteomics and metabolomics (Prof. Lovelace), to understand cellular mechanisms that underlie these complex, progressive disorders.

Speakers

• Genomic approaches toward a greater understanding of Alzheimer's disease
  Alison Goate — Neuroscience, Icahn School of Medicine at Mount Sinai


• De-mystifying microglia during neurodegeneration using transcriptomic and epigenomic approaches
  Li-Huei Tsai — Brain and Cognitive Sciences, Massachusetts Institute of Technology


• Multiscale Network models of Alzheimers Disease
  Bin Zhang — Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai


• Blood metabolite markers of Alzheimers disease: Promise and challenges
  Madhav Thambisetty — Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH