SIRT1 in muscle health and disease

Symposium — Sunday, April 23, 2024 — 8:00 AM - 10:00 AM — , Room W190B
Environmental and Exercise Physiology Section — Chair: Vladimir Ljubicic — Co-Chair:

The rapid expansion of our knowledge of SIRT1 as an important modulator of muscle phenotype has been caused, in part, by the identification that SIRT1 governs the behavior of critical regulators of skeletal muscle biology. A number of studies have noted that SIRT1 expression and activity are altered in skeletal muscle in response to acute or chronic stress, in parallel with the remodeling of myofibers. However, other studies have found little, or no, association of SIRT1 with muscle adaptation. Indeed, there are many unanswered questions relating to SIRT1 in the context of skeletal muscle biology. Our aim in this symposium is to provide an overview of the potential roles of SIRT1 in regulating skeletal muscle plasticity in health and disease. An international panel of speakers will share diverse expertise and insight on muscle SIRT1 biology. We hope to demonstrate a synergy in the experimental approaches that we employ to examine SIRT1 expression, regulation and function in skeletal muscle. Our symposium will underscore the importance of SIRT1 in muscle health and disease and highlight new research directions for SIRT1 biology on the horizon.

Speakers

• The role of SirT1 in muscle mitochondrial adaptations to exercise
  David A. Hood — Kinesiology and Health Science, York University


• Understanding the role of SIRT1 in humans: What can we learn from exercise, nutrition and Resveratrol?
  Brendon J. Gurd — Kinesiology and Health Science, Queen's Univeristy


• The role of SIRT1 in skeletal muscle hypertrophy
  Andrew Philp — Sport, Exercise and Rehabilitation Sciences, University of Birmingham


• SIRT1 in skeletal muscle repair
  Stephen E Alway — School of Medicine, University of West Virginia