Exercise training versus metformin for the treatment of cardiometabolic diseases

Symposium — Tuesday, April 25, 2024 — 8:00 AM - 10:00 AM — , Room W190B
Environmental and Exercise Physiology Section — Chair: William G Schrage — Co-Chair: Nathan Jenkins

The epidemic of cardiometabolic disease can be treated with effective exercise, but exercise is often not tolerated such that the use of pharmacologic agents to improve cardiovascular and metabolic health (eg insulin sensitivity) is warranted. The benefits of both treatments may not necessarily act in a complementary fashion; in fact, metformin may reduce the effectiveness of exercise. The goal of this symposium is to present ideas relating the interactions and interference between classic exercise training interventions and the physiology of metformin, the current standard of care drug treatment for patients with type 2 diabetes.  The target audience is a broad group of physiologists that are reaching across disciplines to understand cardiovascular, endocrine, and exercise physiology in a more integrative fashion solve the complex pathophysiology of cardiometabolic disease. The symposium will bring together experts in both animal models and human disease who are studying the interactions between exercise training and metformin treatment. Data will span cellular, organ, and whole body function in vascular, hepatic, adipose, and skeletal muscle systems and the impact of changes in these systems on overall cardiovascular health.

Speakers

• Exercise and metformin effects on insulin action risk factors in adults
  Barry Braun — Health and Exercise Science, Colorado State University


• Interactive effects of exercise and metformin treatment on the vasculature and adipose tissue in obesity and type 2 diabetes
  Nathan Jenkins — Kinesiology, University of Georgia


• Exercise training vs. metformin on NAFLD-related outcomes and hepatic lipid metabolism.
  Scott Rector — Nutrition and Exercise Physiology, University of Missouri-Columbia


• Exercise and metformin effects on fitness, CV markers and hepatic fat in children 
  Nelly Mauras — Nemours Childrens Clinic, Mayo College of Medicine