Adipose Tissue and the Cardiovascular System: Interactions with Sleep and Cardiometabolic Risk Factors

Symposium — Monday, April 24, 2024 — 10:30 AM - 12:30 PM — , Room W196B
Cardiovascular Section — Chair: Naima Covassin — Co-Chair: Maik Gollasch

Obesity plays an important role in the development of cardiometabolic disorders. Among the various contributing factors to obesity-related pathophysiology, alterations in regional adipose tissue depots along with molecular and cellular characteristics of adipose tissue are known to contribute to hypertension, insulin resistance, atherosclerosis, and cardiovascular disease. Importantly, recent epidemiological and experimental studies also suggest an association between aberrant sleep patterns and cardiometabolic risk, with altered adipose tissue function as possible mediator in the relationship. This symposium seeks to bring together researchers to present their findings regarding the role and mechanisms by which regional adipose tissue influence cardiovascular function in health and disease. The emerging role of abnormal sleep as a potential cause of adipose tissue dysfunction and as a novel cardiovascular health hazard will be illustrated. By encouraging interaction between experts in obesity, adipose tissue biology, sleep medicine, and vascular disease, this symposium will provide the audience with a summary of current knowledge regarding the complex interactions between adipose tissue, sleep and the cardiovascular system, and will address key areas/questions that need to be further explored.

Speakers

Role of adipose tissue in cardiometabolic disorders: an overview
Prachi Singh — Department of Cardiovascular Diseases, Mayo Clinic

GPCR signaling in brown/beige adipose tissue
Alexander Pfeifer — Institute of Pharmacology and Toxicology, University of Bonn

The role of perivascular adipose tissue in atherosclerosis and hypertension
Eugene Chen — Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan

Interactions between sex, sleep, and body composition
Marie-Pierre St. Onge — New York Obesity Nutrition Research Center, Institute of Human Nutrition, Columbia University