Exercise Intolerance in Metabolic, Pulmonary and Cardiovascular Diseases: Did We Forget the Brain?

Symposium — Tuesday, April 25, 2024 — 3:15 PM - 5:15 PM — , Room W375A
Integrative Physiology Symposium Series — Chair: Patrice Brassard — Co-Chair: Damian M. Bailey

Although cerebral blood flow and oxygenation do not seem to influence exercise tolerance in healthy individuals at sea level, a reduction in cerebral oxygen levels may account for the attenuated exercise performance of healthy individuals in hypoxia. Recent evidence suggests that diminished cerebral blood flow and/or oxygenation may be limiting factors of exercise capacity in patients with type 2 diabetes, heart failure, without or in combination with chronic obstructive pulmonary disease, and pulmonary arterial hypertension. This cross-sectional symposium aims to highlight the impact of different clinical conditions on cerebral blood flow regulation during exercise and how reductions in perfusion and oxygenation to the brain have the potential to influence exercise tolerance. Following a brief presentation of the methods used to monitor cerebral blood flow and oxygenation at rest and during exercise in humans, and the main determinants of cerebral blood regulation and oxygenation during exercise, each speaker in this symposium will then address a specific disease state and the mechanisms underlying the potential influence of flow and oxygen levels to the brain on the capacity to perform exercise.

Speakers

• Cerebral Blood Flow and Oxygenation in Humans: Dynamic Evaluation and Regulation during Exercise
  Damian M. Bailey — Faculty of Life Sciences and Education, University of South Wales


• Cerebral Blood Flow and Oxygenation during Exercise in Patients with Heart Failure and Pulmonary Arterial Hypertension
  Patrice Brassard — Kinesiology, Université Laval


• Cerebral Blood Flow and Oxygenation During Exercise in Patients With a Combination of Chronic Obstructive Pulmonary Disease and Heart Failure
  Mayron F. Oliveira — Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Respiratory Division, Department, Federal University of São Paulo


• Cerebral Blood Flow and Oxygenation during Exercise in Patients with Type 2 Diabetes
  Johannes Van Lieshout — Cardiovascular Research Institute Amsterdam and Dept. of Medicine,, University of Amsterdam