New insights into the regulation of renal blood flow in health and disease

Symposium — Wednesday, April 26, 2024 — 10:30 AM - 12:30 PM — , Room W194B
Renal Section — Chair: Aaron Polichnowski — Co-Chair: Jan Williams

Renal autoregulation, via myogenic and tubuloglomerular feedback (TGF) mechanisms, is thought to play an important role in regulating renal function and protecting against hypertensive renal damage.  During the last 5-10 years, significant progress has been made regarding various factors, such as reactive oxygen and nitrogen species, that modulate myogenic and TGF responses and thus can greatly influence blood pressure and susceptibility to hypertensive renal injury.  Moreover, several new analytical approaches are being utilized in isolated renal arterioles as well as in both anesthetized and conscious animals in order to gain a better understanding of the underlying mechanisms of autoregulation. These studies have led to some major insights regarding the regulatory and protective roles of renal autoregulation as well as the relative contribution of the underlying mechanisms in the context of physiology and pathophysiology. The purpose of this symposium is to provide a forum on which to exchange ideas and discuss the broader implications of these data on our understanding of renal autoregulation. Experts in the field of renal hemodynamics with a broad range of experimental and analytical approaches will undoubtedly provide a much needed update in this area and should generate considerable excitement over a wide range of APS sections.     

Speakers

• The physiological significance of TGF response in the long-term control of sodium excretion and blood pressure
  Ruisheng Liu — Department of Pharmacology and Physiology, University of South Florida


• ROS differentially regulate myogenic tone     
  Chris Wilcox — Medicine, Division of Nephrology  Hypertension, Georgetown University Medical Center


• The role of NADPH oxidase subunit p67phox in the regulation of renal function in Dahl S rats    
  Louise Evans — Physiology, Medical College of Wisconsin


• Renal autoregulation and dynamics of glomerular BP transmission in conscious rats: novel analysis methods and insights
  Karen Griffin — Medicine, Loyola University