Regulation of glomeruli physiological function: podocytes and beyond

Symposium — Tuesday, April 25, 2024 — 10:30 AM - 12:30 PM — , Room W192C
Renal Section — Chair: Daria Ilatovskaya — Co-Chair: Jochen Reiser

The symposium will focus on the functional properties of the major renal filtration unit  glomerulus - and its contribution to the body fluid homeostasis. Numerous kidney diseases are associated with improper function of glomerular filtration barrier due to damage of glomerulus and its epithelial cells  podocytes. Genetic discoveries further highlighted multiple podocyte-associated genes that lead to human diseases. Advancing current knowledge of the podocytes pathobiology is of critical importance for the understanding of how glomeruli dysfunction contributes to the creation of the pathologic fluid and electrolyte imbalance, proteinuria and progress to renal failure. While podocytes are critical cells in the glomerulus, this session will be broader and will not exclude other cell types and functions of glomeruli.  Suggested talks will be given by the leading scientists in the field, and will cover current view on glomeruli function from the clinical point, feature technical advances which have recently allowed the researchers to study glomeruli in vivo, and specifically will highlight novel mechanisms mediating changes in glomeruli function that lead to glomeruli disease. 

Speakers

• Glomerular endothelium and its interactions with podocytes
  Susan Quaggin — Medicine, Northwestern University


• Using 2-photon microscopy to understand albuminuria
  Bruce Molitoris — Medicine, Indiana University


• Role of TRPC channels in the pathobiology of podocytes
  Oleg Palygin — Physiology, Medical College of Wisconsin


• Proteostatic mechanisms in glomerular pathophysiology
  Markus Rinschen — Internal Medicine II - Kidney Research Center, University of Cologne