2017 Abstracts American Physiological Soceity Experimental Biology Information

Central GLP-1 receptors in the regulation of energy homeostasis

Symposium — Tuesday, April 25, 2024 — 3:15 PM - 5:15 PM — , Room W192B
Endocrinology and Metabolism Section — Chair: Wolfgang Langhans — Co-Chair:

 Glucagon-like peptide 1 (GLP 1) is secreted from intestinal L-cells in response to luminal nutrient stimulation, and from neurons in the caudal brainstem. Endogenous GLP-1 enhances glucose-induced insulin secretion and inhibits gastric emptying as well as eating. Also, it is well-established that peripheral or central administration of native GLP 1 or GLP-1 receptor (GLP-1R) agonists recapitulate these actions. Because of their incretin and eating-inhibitory effects, GLP-1R agonists have emerged as promising tools for the pharmacotherapy of type 2 diabetes (T2D) and obesity. Several GLP-1 analogs with different pharmacokinetics and pharmacodynamics are currently available in the clinic. The mechanisms underlying the eating-inhibitory and incretin effects of GLP-1R agonists are, however, still elusive because they activate complex neural pathways and generate autonomic and neuroendocrine responses, all of which may contribute to the behavioral and metabolic outcomes. In the proposed symposium, four outstanding speakers will highlight exciting recent developments in relation to the questions of where exactly GLP-1R agonists act to inhibit eating and improve glycemic control, and what the underlying mechanisms of these beneficial effects are.

Speakers

  •  Vagal neuropeptide CART is required to mediate physiological effects of gut GLP1
    Guillaume De Lartigue — John B Pierce Lab, Yale

  • Emerging role of endogenous central GLP-1 in brown adipose tissue thermogenesis
    Shin Lee — Dept. of Health Sciences and Technology, ETH Zurich

  • Insights into the cellular and molecular signaling events of the central GLP-1 receptor
    Matthew Hayes — Department of Psychiatry, University of Pennsylvania

  •  Neural substrates engaged by GLP-1 to impact on feeding and reward; unexpected role of interleukins and sex steroids
    Karolina Skibicka — Institute of Neuroscience and Physiology, University of Gothenburg