The Emerging Role of Lipids in Lung Physiology and Disease

Symposium — Monday, April 24, 2024 — 3:15 PM - 5:15 PM — , Room W196A
Respiration Section — Chair: Wolfgang M. Kuebler — Co-Chair: Eleftheria Letsiou

Over recent years, lipid mediators have become recognized as a central and ubiquitous group of signaling molecules that regulate a broad palette of cellular functions and responses including cell death, proliferation, differentiation, contraction, ion channel activity, to name a few. Lipid mediators such as resolvins, sphingolipids, or lysophosphatidic acid are increasingly recognized as important regulators of lung functions in health in disease. This symposium will highlight the critical roles of lipid mediators in four major lung diseases: asthma, acute lung injury, pulmonary hypertension, and lung fibrosis. The presentations will cover novel signaling roles of lipids and mechanisms of disease, and will also discuss translational and clinical data that demonstrate the relevance of these signaling pathways for human disease. 

Speakers

• Resolvins and maresins in lung inflammation
  Raja-Elie Abdulnour — Medicine, Brigham & Women's Hosp.


• Cholesterol-Mediated Surfactant Dysfunction in Ventilator-Induced Lung Injury
  Ruud Veldhuizen — Physiology and Pharmacology, Univ. of Western Ontario


• Mechanisms of Ceremide-Induced Endothelial Barrier Failure and Acute Lung Injury
  Stefan Uhlig — Lehrstuhl für Pharmakologie und Toxikologie, Univ. of Aachen


• Sphingosine-1-Phosphate Signaling in Pulmonary Hypertension
  Roberto Machado — Medicine, Univ. of Illinois at Chicago


• Source and Functional Relevance of Lysophosphatidic Acid in Pulmonary Fibrosis
  Andrew Tager — Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital