Vasodilation in human microvessels: from bed to bench and back

Flex Session — Wednesday, April 26, 2024 — 2:30 PM - 4:30 PM — , Room W196A
Translational Physiology Interest Group — Chair: Petra Kleinbongard — Co-Chair: Karima Ait-Aissa

Vascular homeostasis is highly dependent connected the genetic and environmental modifiers which can change or inhibit mechanism of vasodilation. The study of animal models has brought great insights into these complex pedigrees of vascular signaling, but in order to facilitate clinical applications further evidence in human studies needs to be gathered. There are a number of factors released from the endothelium, circulation or surrounding matrix. A high degree of redundancy exists in this regulation which may have important implications for blood flow in disease. In this symposium, mechanisms of dilation in health and disease will be presented.  The role of role of the mitochondria and its importance in producing vasodilators from the endothelium will be presented.  Better understanding the mechanism of vasodilation in health and disease could profoundly impact our knowledge regarding vascular pathology including atherosclerosis, hypertension and endothelial dysfunction.  The goal of this symposium is to present cutting edge innovative research in vascular physiology that will be both provocative and educational. 

Speakers

• Vascular effects of exercise and other lifestyle factors in humans
  Shane A Phillips — Department of Integrative Physiology, University of Chicago at Illinois


• Ischemic Preconditioning as an Intervention to Improve Motor Function in Stroke Subjects - Vascular and Neural Considerations
  Matt Durand — Physical Medicine and Rehabilitation, Medical College of Wisconsin


• Remote preconditioning effect on vasculature and myocardium  
  Petra Kleinbongard — Institute of Pathophysiology, University of Essen


• Healthy aging in the human vasculature contributions of external stressors on endothelial function
  Anthony J Donato — Geriatrics, University of Utah


• Role of Autophagy in endothelial cell function in Diabetics 
  Jessica L Fetterman — Medicine, Boston University School of Medicine