Hydration and Vasopressin Beyond the Kidney

Flex Session — Wednesday, April 26, 2024 — 2:30 PM - 4:30 PM — , Room W190A
Water and Electrolyte Homeostasis Section — Chair: Stavros Kavouras — Co-Chair: Lise Bankir

With the emerging evidence that high circulating vasopressin (AVP) is anindependent risk factor for diabetes and cardiometabolic disease, a reduction of AVPsecretion through water supplementation is an attractive candidate intervention toprevent the risk of diabetes, obesity and their cardiovascular complications. Besidesthe antidiuretic actions of this hormone, well characterized in the last century, anemerging amount of evidence appeared in the last decade, linking AVP-regulatedwater homeostasis to health outcomes. Vasopressin remains a key player in totalwater body regulation by acting on the kidney to conserve water, but it is clear nowthat the effects of AVP are not limited to water balance; its actions also includeglycogenolysis and gluconeogenesis in the liver, glucagon and/or insulin release bypancreatic islets, a complex balance between vasoconstriction of vascular smoothmuscle cells and vasodilation of these cells by NO release from the endothelium, andACTH release from the anterior pituitary. These effects are mediated by the V1a andV1b receptors, as well as by extra-renal V2 receptors.

From central effects to peripheral actions, this session will explore the diversity ofAVPs functions and multiple roles beyond it's role on the kidney. First, the sessionwill describe the physiology and pathophysiology of central vasopressin release andperception of thirst. Second, the session will focus on key physiological functions ofAVP in peripheral vascular resistance and responses to stress. Finally as plasmaAVP is largely determined by fluid intake and associated with urinary hydrationbiomarkers, the session will give new perspectives on the new potential role of AVPas a risk factor in the study of vascular and metabolic diseases.

Speakers

• Central Effects of Vasopressin in the brain
  Daniel Bichet — Dept. of Medicine, Univ. of Montreal


• The Vasopressin Paradox: Not a Vasoconstrictor?
  Georges Bakris — , Univ. of Chicago


• Vasopressin as a Stress Hormone
  Ivan Tack — Svc Explo Fonct Renales, CHU Toulouse, Hopital Rangueil


• From (De)Hydration Science towards Biomarkers for Hydration for Health
  Jeanne Bottin — , Danone Nutricia Research