Exploring Novel Mechanisms to Improve Exercise Tolerance in Health and Disease

Featured Topic — Sunday, April 22, 2024 — 1:30 PM - 3:00 PM — Convention Center, Room 25B
Environmental and Exercise Physiology Section — Chair: Ryan A Harris — Co-Chair: Jill N Barnes

    Epidemiological data supports that those who are physically active have an improved well-being and reduction in overall risk to many chronic diseases.  Decreased exercise capacity (VO2 peak), an objective measurement of exercise tolerance, is often observed in many disease states.  Physical inactivity alone is not always the root cause for exercise intolerance and oxygen delivery, transport and utilization all play a key role.  In fact, abnormal oxygen content, lung dysfunction, vascular dysfunction, and mitochondrial dysfunction may all contribute to lower exercise capacity in both health and disease. Investigating any of the aforementioned biological systems, the proposed featured topic will showcase state-of-the-art physiology and present novel mechanisms that contribute to exercise intolerance in health and disease.

Speakers

• Mechanism and consequences of O2 supply limitations in heart failure.
  Markus Amann — Medicine, University of Utah


• Central Cardiac Determinants of the Speed-duration Relationship in Heart Failure Rats
  Jesse C Craig — Kansas State University


• Inorganic nitrate supplementation improves exercise tolerance and calf vascular function in patients with peripheral artery disease
  Joshua Bock — University of Iowa


• Skeletal Muscle Parvin Regulates Exercise Tolerance and Glucose Homeostasis in Mice.
  Daniel Stephen Lark — Vanderbilt University


• Acute Sildenafil Treatment Improves Exercise Capacity in Patients with Cystic Fibrosis
  Vincent Gonzalez — Medical College of Georgia


• CHAIR
  Ryan Harris —


• COCHAIR
  Jill Barnes —