Organoids: Modelling Cell Physiology and Disease in 3D

Symposium — Sunday, April 22, 2024 — 1:30 PM - 3:00 PM — Convention Center, Room 28A
Cell and Molecular Physiology Section — Chair: Neil A Bradbury — Co-Chair: Nadia Ameen

Standard tissue culture techniques have proven invaluable in elucidating many of the mechanisms and proteins underlying normal and disease physiology at the cell level.  However the desire of my scientists is to recapitulate the native environment of cells as much as possible.  Organoids have led the way in this endeavor, with many human and animal cells being isolated as primary cells, and allowed to self-propagate in a 3-dimensional matrix, yielding a structure that recapitulates the organ of origin.  The proposed symposium will bring together scientists who are utilizing organoid cultures, as well as those at the forefront of technique development.  The aim of the symposium is to provide the audience not only with an insight into what is being done at present, but also a platform describing how the audience can start their own organoid studies.  Confirmed speakers include Drs Tuveson, Danahay and Bradbury who will describe the use of pancreatic, airway and intestinal organoids to elucidate normal and disease physiology.  Excitingly, speakers from Stem Cell, a leading company in organoid development, will present the latest protocols that will allow any scientist to initiate their own organoid research program. 

Speakers

• Introduction to organoid biology.
  Neil Bradbury — Chicago Medical School


• Human pancreatic organoids as a model for cancer.
  David Tuveson — Cold Spring Harbor Laboratory


• Human enteroids/colonoids to understand the pathophysiology of GI diseases.
  Nicholas C. Zachos — Div of Gastroenterology & Hepatology, Johns Hopkins Univ. Sch. of Med.


• Getting organoids started in your own laboratory.
  Ryan Conder — StemCell Technologies


• COCHAIR
  Nadia Ameen — Yale University