Molecular Mechanisms for Salt-Induced Cardiovascular Disease
Symposium — Tuesday, April 24, 2024 — 8:30 AM - 10:00 AM — Convention Center, Room 24
Cell and Molecular Physiology Section — Chair: Annet Kirabo — Co-Chair: Natalia Ruggeri Barbaro
Cardiovascular disease is the number one cause of global mortality and disability due to stroke, myocardial infarction, heart failure and kidney disease. According to the 2017 American Heart Association report, 131.2 million Americans are projected to have cardiovascular disease by the year 2035, which will be nearly HALF of the U.S. population. Reducing salt intake by 3 g/day in the U.S. has been estimated to reduce the annual number of new cases of coronary heart disease and stroke by 20%, and yet the mechanisms by which salt contributes to blood pressure elevation and cardiovascular disease remain unclear. Several organ systems have been found to contribute to the pathogenesis of cardiovascular disease including the autonomic nervous system, cardiovascular system, renal system and recently, the immune system. This session will highlight the molecular mechanisms by which excess dietary salt leads to a perturbation of the cellular homeostasis in these organ systems leading to cardiovascular disease.
Speakers
- Salt, iflammation, and NKCC2.
Steven Crowley — Medicine, Duke University School of Medicine
- Renal nerves and renal inflammation in salt-induced hypertension: Afferent or efferent?.
John Osborn — Integrative Biology and Physiology, University of Minnesota
- The brain and Salt Sensing in Cardiovascular Disease.
Sean Stocker — Hypertension Center, University of Pittsburgh
- CHAIR
Annet Kirabo —
- COCHAIR
Natalia Ruggeri Barbaro —
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