Getting Blood to Where it Needs to Go: Emerging Mechanisms Regulating Skeletal Muscle Blood Flow in Health and Disease

Featured Topic — Tuesday, April 24, 2024 — 8:30 AM - 10:00 AM — Convention Center, Room 25B
Environmental and Exercise Physiology Section — Chair: Steven A. Romero — Co-Chair: Christopher Hearon

Like a well-orchestrated symphony, the skeletal muscle vasculature has numerous mechanisms that work in concert to regulate blood flow. With disease, these mechanisms can be altered and/or impaired resulting in malperfusion of skeletal muscle. It is anticipated that the abstract based presenters and keynote speaker will highlight emerging research investigating the underlying mechanisms responsible for vascular maladaptations accompanying varying diseases, in addition to highlighting potential therapeutic approaches to mitigate such detrimental changes within the skeletal muscle. The Featured Topic will cover topics spanning from cellular/molecular signaling pathways identified in animal models, to the integrative control of blood flow in humans. Given the translational and integrative scope of the proposed Feature Topic, it is anticipated that the session will garner widespread attention across the various interest sections of the American Physiological Society and will give rise to a high number of abstract submissions and session attendees. Finally, the proposed Feature Topic will also serve to stimulate discussion and provide direction for further avenues of research within this important and evolving field of study.

Speakers

• Mechanisms of Age-related Compensatory Vasodilation: Insight from Passive Leg Movement
  Joel D Trinity — Salt Lake City VAMC


• Augmented Skeletal Muscle Vasodilation to Intravascular ATP During Exercise and Systemic Hypoxia in Humans
  Janée D. Terwoord — Colorado State University


• Endothelium Mediated Dilation Does Not Blunt α1-adrenergic Vasoconstriction in First Order Arterioles
  Brian S Ferguson — University of Illinois at Chicago


• Effect of Increased Skeletal Muscle Temperature on Intramuscular Histamine Concentrations
  Joshua Mangum — University of Oregon


• Limiting the constrictor influence: a parallel tale on scientific mindset and vascular control in humans.
  Frank Dinenno — Department of Health and Exercise Science, Colorado State University


• CHAIR
  Steven Romero —


• COCHAIR
  Christopher Hearon —