Role of the Microbiome in Cardiovascular Disease (Supported by Journal of Clinical Science)

Featured Topic — Sunday, April 22, 2024 — 8:30 AM - 10:00 AM — Convention Center, Room 24
Cardiovascular Section — Chair: Emmanuel Buys — Co-Chair:

Having high blood pressure puts you at risk for heart disease and stroke, which are leading causes of death in the united states and worldwide. One out of every three Americans has hypertension and it is estimated that despite aggressive treatment with medications, only about half of those medicated have managed blood pressure. Recent discoveries of the oral microbiome that reduce inorganic nitrate to nitrite and nitric oxide provide a new therapeutic target for the management of hypertension. The presence or absence of select and specific bacteria may determine steady state blood pressure levels. Eradication of oral bacteria through antiseptic mouthwash or over use of antibiotics causes blood pressure to increase. Allowing recolonization of nitrate and nitrite reducing bacteria can normalize blood pressure. This lecture will provide evidence of the link between oral microbiota and the production of nitric oxide and regulation of systemic blood pressure. Management of systemic hypertension through maintenance of the oral microbiome is a completely new paradigm in cardiovascular medicine.

Speakers

• The oral microbiome and hypertension.
  Nathan Byran — Department of Molecular & Human Genetics, Baylor College of Medicine


• Suppression of the Gut Microbiome-Derived Metabolite Trimethylamine N-oxide Prevents Western Diet-Induced Arterial Dysfunction
  Vienna E Brunt — University of Colorado Boulder


• Examining the Role of Gut Dysbiosis in Neuroinflammation and Hypertension in a Model of Obstructive Sleep Apnea
  David Durgan — Baylor College of Medicine


• Short-term captopril treatment causes persistently decreased blood pressure associated with long-lasting shifts in gut microbiota and improvement in gut pathology
  Tao Yang — University of Florida


• Dysbacteriosis an Inciting Cause of Endothelial Dysfunction mediated through Mitochondrial DNA Interactions
  Karima Ait-Aissa — Medical College of Wisconsin


• CHAIR
  Emmanuel Buys —