Post-Translational Modifications in Cardiovascular Disease

Featured Topic — Wednesday, April 25, 2024 — 8:30 AM - 10:00 AM — Convention Center, Room 25B
Cardiovascular Section — Chair: Iain Scott — Co-Chair: Mark J. Kohr

Post-translational modifications permit cells to rapidly adapt to changing conditions without generating new proteins. In the heart, post-translational modifications have been implicated in the control of numerous cellular systems, including mitochondrial metabolism, contractile protein dynamics and nutritional signaling pathways. In this session we will provide an overview of this rapidly expanding field, and investigate new mechanisms in cardiac pathophysiology that are regulated by the post-translational modification of cellular proteins.

Speakers

• Lysine acetylation in cardiac pathophysiology.
  Mahesh Gupta — Department of Surgery, University of Chicago


• Increased global lysine acetylation in diabetic vasculature is associated with downregulation of SIRT-1 in vascular smooth muscle cells.
  Christina Mary Johnson — New York Institute of Technology College of Osteopathic Medicine


• Neddylation is Essential for Cardiac Development via Regulation of Notch Signaling
  Rodney Eric Littlejohn — Augusta University


• Metabolic Interventions to Treat Mitochondrial Cardiomyopathy: Roles of NAD+ and Protein Acetylation in Leigh Syndrome
  Chi Fung Lee — University of Washington


• Increased Protein Cysteine Sulfonation with Heme Destruction of Mitochondrial Complex III Mediates Cardiac Reperfusion Injury
  YEONG-RENN CHEN — Northeast Ohio Medical University


• CHAIR
  Iain Scott —


• COCHAIR
  Mark Kohr —