From Gene to Function of Complex Traits: Analysis of Genes Identified in Human GWAS and Animal Models

Featured Topic — Sunday, April 22, 2024 — 1:30 PM - 3:00 PM — Convention Center, Room 28B
Physiological Omics Group — Chair: Leah Solberg Woods — Co-Chair:

Although several genes and gene regions have been identified for a multitude of complex traits, the underlying causal variant and downstream function of most of these genes are unknown.  The current session sets out to highlight work that has been done identifying both causal variants, as well as determining function of these genes.  We welcome work conducted for phenotypes underlying multiple diseases and complex traits including diabetes, obesity, kidney disease, heart disease, drug addiction, psychiatric disorders and others. Work from human genome wide association studies and animal models is welcome.

Speakers

• Learning about an old dog's new tricks: the role of Glyoxalase 1 in regulating behavior and GABAergic signaling and how we stumbled across it.
  Abraham Palmer — Department of Psychiatry, University of California San Diego


• The IMPC: A Global Scientific Infrastructure for Understanding the Role of Genes in Complex Traits
  Violeta Muñoz-Fuentes — EMBL-EBI


• Characterization of Coding and Noncoding Variants for Human CKD Using Novel Strategies
  Jeremy W Prokop — Michigan State University


• GNAI2 Polymorphic Variance Associates with the Salt-Sensitivity of Blood Pressure
  Alissa A Frame — Boston University School of Medicine


• Tick-Tock, Tick-Tock: Clock Gene Expression is Altered in Sleep Apnea
  Meaghan Holzworth — University of Florida


• CHAIR
  Leah Solberg Woods —