The Role of REDD1 in the Regulation of Skeletal Muscle Metabolism
Symposium — Monday, April 23, 2024 — 1:30 PM - 3:00 PM — Convention Center, Room 28A
Endocrinology and Metabolism Section — Chair: Francois Favier — Co-Chair:
The stress-induced protein, Regulated in Development and DNA Damage 1 (REDD1), has been implicated in the pathophysiology and physiology of a variety of conditions in which skeletal muscle mass and function are altered including cancer cachexia, alcohol abuse, hypoxia, sepsis, insulin resistance, muscle overload/resistance exercise, nutrient consumption, and aerobic exercise. The overwhelming majority of research has focused on its role as a repressor of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1), which is a central metabolic integration point and regulator of metabolic function. In all, the proposed symposium will shed light onto an emerging regulatory protein involved with numerous aspects of skeletal muscle metabolism.
Speakers
- REDD1- mediated redox control governs autophagy and skeletal muscle ATP generation to promote exercise capacity.
Leif Ellisen — Massachusetts General Hospital
- The role of REDD1 during muscle hypertrophy and atrophy.
Scot Kimball — Pennsylvania State University College of Medicine
- The role of REDD1 in the exerciseinduced change in gene expression.
Bradley Gordon — University of Central Florida
- CHAIR
Francois Favier —
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