Mechanisms underlying Skeletal Muscle Adaptation in Health and Disease

Symposium — Tuesday, April 24, 2024 — 8:30 AM - 10:00 AM — Convention Center, Room 22
Endocrinology and Metabolism Section — Chair: Charles Lang — Co-Chair: Patricia Molina

 The mass and functional capacity of skeletal muscle are tightly regulated by contractile activity, nutrient supply and hormones. Contractile activity is necessary for postnatal muscle growth and for the maintenance of muscle mass in adults, and increased work can cause fiber hypertrophy. Conversely, disuse or denervation causes rapid atrophy. Skeletal muscle also serves as the organisms major protein reservoir from which amino acids can be mobilized for gluconeogenesis, new protein synthesis or as an energy store. Consequently, upon food deprivation and in many systemic disease states, including sepsis, cancer, burn injury, diabetes, cardiac and renal failure, there is a generalized muscle wasting, which results primarily from increased breakdown of muscle proteins, although protein synthesis also falls in most of these conditions. In all these systemic catabolic states, the loss of muscle mass involves a common pattern of transcriptional changes, including induction of genes for protein degradation and decreased expression of various genes for growthrelated and energy-yielding processes. This symposia is designed to highlight recent advances in selected aspects of the regulation of muscle protein balance, specifically, protein synthesis, ubiquitin-proteasome degradation, autophagy, and muscle regeneration.

Speakers

• Proteasomal activation in remodeling muscle during aging and disuse.
  Sue Bodine — Internal Medicine - Endocrinology and Metabolism, University of Iowa


• Impact of impaired stem cell differentiation on alcohol-induced muscle wasting.
  Liz Simon — Physiology, LSU Health Science Ctr.


• Changes in muscle protein synthesis: role in catabolic muscle loss in humans.
  Stuart Phillips — Kinesiology, McMaster University


• CHAIR
  Charles Lang —


• COCHAIR
  Patricia Molina —