Extracellular Matrix Remodeling in Metabolic Diseases

Symposium — Wednesday, April 25, 2024 — 8:30 AM - 10:00 AM — Convention Center, Room 20A
Integrative Physiology Symposium Series — Chair: Sue C. Bodine — Co-Chair: David H. Wasserman

The extracellular matrix (ECM) is a highly-dynamic compartment that undergoes remodeling as a result of injury and repair. Over the past decade, mounting evidence in humans and rodents suggests that ECM remodeling is associated with diet-induced insulin resistance in several metabolically active tissues. In addition, integrin receptors for the ECM have also been implicated in the regulation of insulin action in muscle and liver. This session addresses what is currently known about the ECM, integrin signaling, and insulin action in the muscle, liver, and adipose tissue. Understanding how ECM remodeling and integrin signaling regulate insulin action may aid in the development of new therapeutic targets for the treatment of insulin resistance and type 2 diabetes (T2D).

Speakers

• Adipose extracellular matrix remodeling in development and obesity.
  Tae-Hwa Chun — Medicine, University of Michigan


• Increased extracellular matrix abundance characterizes insulin resistant muscle: potential mechanisms.
  Lawrence Mandarino — Medicine, University of Arizona


• Liver extracellular matrix remodeling and integrin signaling in regulation of insulin action.
  David Wasserman — Molecular Physiology and Biophysics, Vanderbilt University