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Ischemic and Hypoxic Conditioning: Potential for Protection of Vital Organs

Symposium — Sunday, April 22, 2024 — 8:30 AM - 10:00 AM — Convention Center, Room 20A
Integrative Physiology Symposium Series — Chair: Caroline A. Rickards — Co-Chair: Justin D. Sprick

Both ischemic and hypoxic conditioning (pre and post injury) have been demonstrated to protect vital organ function in the face of ischemia-reperfusion injury, such as ischemic stroke and myocardial infarction. These novel therapies can be applied either systemically, directly to the organ of interest (heart, brain, muscle), or to a remote location such a limb (i.e., remote ischemic preconditioning, RIPC). The clinical utility of these conditioning stimuli has been mixed, and is the topic of numerous recent reviews in the literature. This session will include presentations exploring the role of ischemic and hypoxic pre- and post-conditioning under a variety of experimental and clinical conditions, and provide insight into recent advances in the field, and important considerations for effective clinical application.

Speakers

  • Intermittent, normobaric hypoxia training exerts robust cerebroprotection against ischemic injury.
    Robert T Mallet — Department of Physiology & Anatomy, Univ. of North Texas Hlth. Sci. Ctr.

  • Prolonged global ischemia and consequences of resuscitation to the heart and brain.
    Justin D. Sprick — Dept. of Physiology and Anatomy, Univ. of North Texas Hlth. Sci. Ctr.

  • Remote ischemic conditioning: Trials, tribulations and clinical translation.
    Karin Przyklenk — Cardiovascular Research Institute, Wayne State Univ. Sch. of Med.

  • CHAIR
    Caroline Rickards —





 

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